WHAT IS LYOPHILIZATION / FREEZE DRYING & FREEZE DRYER?
Freeze drying (also known as “lyophilization” or “cryodesiccation”) is a method used to remove water from frozen material by sublimation of ice crystals. The frozen water in the material (i.e. ice crystals) passes directly from the solid phase to the gas phase by reducing the ambient atmospheric pressure. Thus, lyophilization is a dehydration process used to preserve a perishable material or to make the material more suitable for transport from one place to another.
High-value heat-sensitive materials such as bacteria, fungi, yeast or other microorganism cultures. One of the best ways to store for a long time is using freeze drying. This can be accomplished with a commercially available Freeze Dryer (Lyophilizer) that will preserve your culture collection. Freeze-proof materials can often be lyophilized, so there is no need for refrigerated storage.
Freeze drying has many applications in laboratory, pharmaceutical and biotechnology, food and agriculture-based industries, and technological industries such as chemical synthesis and nanotechnology. Pharmaceutical companies often use freeze-drying to extend the shelf life of live virus vaccines, biologics, and other injectables. In chemical synthesis, freeze-drying is applied to products to make them more durable for subsequent use or to dissolve more easily in water. In nanotechnology, freeze drying is used for nanotube purification to prevent aggregation due to capillary forces during regular thermal evaporation drying.
Lyophilization; It is the freeze-drying process of products. It is generally used for the dehydration of products without losing their basic properties. In principle; it is the process of freezing the product completely and sublimating the formed ice crystals under vacuum atmosphere.
Since it is an application at low temperatures, it is a drying technique that provides dehydration without damaging the molecular and physical structure of the product. Lyophilization process is carried out in devices called Lyophilizer/Freeze Dryer. It is a preferred method for valuable products with high thermal sensitivity.
LYOPHILIZATION/ FREEZE DRYING PROCESS IS CARRIED OUT IN 3 MAIN STAGES;
- Freezing of the Product: It is the process of freezing the product completely and transforming it into crystal form after passing the appropriate preliminary processes.
- Sublimation (Primary Drying): Creating the energy required for sublimation in the frozen product and performing sublimation. It is the stage in which 90-95% of the water content is removed.
- Desorption (Secondary Drying): It is the process of removing the water that cannot be removed in the primary drying and is bound to the substance.
USES OF FREEZE DRYER (LYOPHILIZER):
- Laboratory & Research
- Pharmaceutical and Biological Industry (Drugs, Enzymes, Biological Agents, Cell and Tissue Applications etc.)
- Food Laboratory (Coffee, Herbs, Fruits, Nutraceuticals, Vitamins, Extracts, Animal Products, etc.)
- Dairy Industry – Milk & Curd
- Sugar Cane Industry
- Chemistry Applications
- Museum Recycling (Preservation and recovery of water content such as Books, Wood, Archaeological products, etc.
ADVANTAGES OF FREEZE DRYER (LYOPHILIZER):
- It preserves the shape, color and aromatic structure of the dried product.
- Provides drying without damaging thermally sensitive products
- It offers many alternative preparation and drying possibilities for different product types and quantities (with attachments such as bulk, vial, manifold etc.)
- Possibility of drying the product in the final product container
- Sterile drying facility is available
- Offers Fast Rehydration (rehydration of liberated products)
WHERE TO BUY LABORATORY & PHARMACEUTICAL FREEZE DRYER?
If you are looking for a high quality Laboratory & Pharmaceutical Freeze Dryer, you can find it on the Yatherm Scientific website “yatherm.com“, get in touch with experts and the right choice and develop appropriate solutions.